反应详情

温度

50 °C

A suspension of 5.2 g of ethyl 5-(4-hydroxypiperidino)-2-nitrocinnamate and 1 g of 5% palladium on carbon in 50 ml of acetic acid was stirred under a hydrogen atmosphere at 50° C. for 14 hr. The catalyst was filtrated off and the filtrate was concentrated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography and recrystallized from ethanol to give 1.9 g of 6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril.

1. filtrationThe catalyst was filtrated off
2. concentrationthe filtrate was concentrated under a reduced pressure
3. customThe resulting residue was purified by a silica gel column chromatography
4. customrecrystallized from ethanol