反应详情

To a solution of 100 mg of ethyl 3-chloro-4-trifluoromethylcinnamate and 1.8 ml of concentrated sulfuric acid was added 42 ml of 60% nitric acid at -15° C. After stirring at the same temperature for a few minutes, the reaction mixture was poured into a cold water, and extracted with ethyl acetate. The extract was washed with water, dried, and evaporated. The residue was purified by a silica gel column chromatography to give 102 mg of ethyl 5-chloro-2-nitro-4-trifluoromethylcinnamate.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. customevaporated
5. customThe residue was purified by a silica gel column chromatography