反应详情

The pyrimidinone (0.38 g, 1.22 mmol) is dissolved in 20 ml ethanol and treated with 0.5 g Raney Nickel, 40 psi hydrogen and refluxed for 18 hours. The reaction is cooled, filtered through celite, and the filtrate concentrated in vacuo. The residue is crystallized from ethyl acetate to afford 0.12 g (31.8%) of the dihydro pyrimidinone as a crystalline solid comprising a 7:3 mixture of endo/exo norbornyl isomers.

1. temperaturerefluxed for 18 hours
2. temperatureThe reaction is cooled
3. filtrationfiltered through celite
4. concentrationthe filtrate concentrated in vacuo
5. customThe residue is crystallized from ethyl acetate