L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- → HCID 70045762, compound

HRID 487426Notes

Reaction equation

HRID 487426 reaction equation
[ClH:1].[CH2:2]([O:9][C:10](=[O:19])[CH2:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][C:13]1=[O:18])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(OC([NH:27][C@H:28]([C:36](O)=[O:37])[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=O)(C)(C)C>>[ClH:1].[CH2:2]([O:9][C:10](=[O:19])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([C:36](=[O:37])[C@H:28]([CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[NH2:27])[CH2:14][C:13]1=[O:18])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-HCID 70045499HCID 70045499, compound

Product 1

HCID 70045762HCID 70045762, compoundYield 49.4%

Procedure

2-Oxopiperazine-1-acetic acid benzyl ester hydrochloride (2 g) and N-t-butoxycarbonyl-L-phenylalanine (5.6 g) were subjected to substantially the same procedure as in Working Example 21 to afford 1.5 g of the title compound as amorphous powder.

Sources & evidence

ORD record
ord-3dec453be79b42698138517255e7b91e
Source dataset
uspto-grants-1994_03
Patent number
US05294713

Reaction notes

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