反应详情

1.1 g (3.9 mmol) of 2-amino-7-hydroxy-4-phosphonomethyl-hept-3-enoic acid ethyl ester in 8 ml of water are stirred at 130° C. for 18 hours in a bomb tube. The dark reaction solution is treated with activated carbon and filtered over Hyflo®. The colourless filtrate is concentrated to ~3 ml, and ~25 ml of ethanol are added. The resulting suspension is filtered with suction and dried under a high vacuum at 50° C. 2-amino-7-hydroxy-4-phosphonomethyl-hept-3-enoic acid having a melting point from 190° C. and above (decomp.) is obtained.

1. additionThe dark reaction solution is treated with activated carbon
2. filtrationfiltered over Hyflo®
3. concentrationThe colourless filtrate is concentrated to ~3 ml, and ~25 ml of ethanol
4. additionare added
5. filtrationThe resulting suspension is filtered with suction
6. customdried under a high vacuum at 50° C