Ethanol → HCID 54050720, compound

Participants

Reaction Steps

5.5 g (11.8 mmol) of ethyl 6-ethoxycarbonylmethoxy-2-formylamino-4-diisopropylphosphonomethyl-hex-3-enoate are dissolved in 55 ml of CH2Cl2 and 6.1 ml (42.3 mmol) of trimethylbromosilane are then added dropwise at room temperature to this solution. The reaction mixture is allowed to stand for 24 hours at room temperature and, after the dropwise addition of 55 ml of ethanol, allowed to stand for a further 24 hours. The reaction mixture is concentrated by evaporation, the residue is dissolved in 24 ml of ethanol, and a mixture of 55 ml of propylene oxide and 55 of ethanol is added dropwise to this solution. The suspension so obtained is stirred for 1 hour and then filtered with suction. The filter product is dried giving 2-amino-6-ethoxycarbonylmethoxy-4-phosphonomethyl-hex-3-enoic acid with a melting point of 213°-215° C. (decomp.) as a white oil.

Provenance & Evidence