Triisopropyl phosphite → HCID 86747670, compound

Participants

Reaction Steps

9 g (23.7 mmol) of ethyl 4-bromomethyl-6-ethoxycarbonylmethoxy-2-formylamino-hex-3-enoate and 23.3 ml (94.8 mmol) of triisopropyl phosphite (90%) are heated to 80° C. and stirred for 18 hours under a pressure of 100 mbar. Excess triisopropyl phosphite is removed by distillation and the residue is chromatographed on silica gel with hexane/ethyl acetate 1:3 and then with hexane/ethyl acetate/ethanol (1:3:5%) giving ethyl 6-ethoxycarbonylmethoxy-2-formylamino-4-diisopropylphosphonomethyl-hex-3-enoate as a yellow oil.

Provenance & Evidence