Benzocaine → Ethyl 4-(2,5-dimethyl-1H-pyrrol-1-yl)benzoate

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-ethoxycarbonylaniline (82.6 g), acetonylacetone (68.5 g) and concentrated sulfuric acid (one drop) were heated at 150° C. for one hour. The reaction mixture was diluted with ethyl acetate and washed with water, followed by drying and concentrating, whereby 1-(4-ethoxycarbonylphenyl)-2,5-dimethylpyrrole was obtained.

Provenance & Evidence