Acetic Acid → HCID 14880635, compound

Participants

Reaction Steps

29.2 g (0.15 mol) of 4-chloro-(1,3-dioxolan-2-yl)-aniline and 24.9 g (0.15 mol) of 4(R,S)-methylcyclohexene-1,2-dicarboxylic anhydride were stirred in 250 ml of glacial acetic acid for 3 days at 230° C. and for 10 hours at 70° C.; water was added to induce precipitation, followed by recrystallization and drying. There was obtained 38 g (83%) of N-(4-chloro-3-formylphenyl)-4(R,S)-methyl-3,4,5,6-tetrahydrophthalimide (m.p. 132°-1330° C.).

Provenance & Evidence