反应详情

A mixture of 1-benzyl-imidazole (5 g, 32 mmol), formaldehyde 37% (10 ml, 134 mmol) and sodium hydroxide (100 mg) is refluxed for 7 days and is extracted with ethylacetate. Concentration in vacuo yields 1-benzyl-2-hydroxymethyl-imidazole.

1. temperatureis refluxed for 7 days
2. extractionis extracted with ethylacetate
3. concentrationConcentration in vacuo