Hydrochloric Acid → HCID 19092322, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-6-methylsulfonylamino-1,2,3,4-tetrahydroquinazoline-2,4-dione (158 mg) in methanol was added 10% hydrogen chloride in methanol solution (123 mg) at 5° C. After stirring for 1 hour at 5° C., the solution was evaporated. The residue was crystallized from isopropyl alcohol-ethyl acetate to give 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-6-methylsulfonylamino-1,2,3,4-tetrahydroquinazoline-2,4-dione hydrochloride (81 mg).

Provenance & Evidence