Semicarbazide hydrochloride → 2-Phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde semicarbazone

HRID 487609Notes

Reaction equation

HRID 487609 reaction equation
[C:1]1([C:7]2[C:15]([CH:16]=O)=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:19][NH:20][C:21]([NH2:23])=[O:22]>C(O)C>[C:1]1([C:7]2[C:15]([CH:16]=[N:19][NH:20][C:21]([NH2:23])=[O:22])=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 11236Semicarbazide hydrochlorideHCID 151581792-Phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde

Product 1

HCID 539329452-Phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde semicarbazoneYield 41.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde (0.5 g) and semicarbazide hydrochloride (0.25 g) in ethanol (7ml) was refluxed for 1 hour and then cooled. The resulting precipitates were filtered and recrystallized from a mixture of water and ethanol to give 2-phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde semicarbazone (0.26 g).

Workup

  1. temperaturewas refluxed for 1 hour
  2. temperaturecooled
  3. customThe resulting precipitates
  4. filtrationwere filtered
  5. customrecrystallized from a mixture of water and ethanol

Sources & evidence

ORD record
ord-81c118bedada42358d6f26aafc06b967
Source dataset
uspto-grants-1994_03
Patent number
US05296490

Reaction notes

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