反应详情

A mixture of methyl 3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acrylate (trans isomer) (4.05 g) in 1N sodium hydroxide solution (58.3 ml) and methanol (80 ml) was refluxed for 1 hour and evaporated in vacuo. The residue was dissolved in water and washed with chloroform. The aqueous layer was acidified with 1N hydrochloric acid. The resulting precipitates were filtered and recrystallized from isopropyl alcohol to give crystals of 3-(2-phenylpyrazolo[1,5-a]-pyridin-3-yl) acrylic acid (2.65 g).

1. temperaturewas refluxed for 1 hour
2. customevaporated in vacuo
3. dissolutionThe residue was dissolved in water
4. washwashed with chloroform
5. customThe resulting precipitates
6. filtrationwere filtered
7. customrecrystallized from isopropyl alcohol