Hydrochloric Acid → HCID 19092748, compound

Participants

Reaction Steps

To a solution of 2-cyanomethoxy-5-methoxybenzaldehyde (420.0 g) in N,N-dimethylformamide (2.1 l), sodium hydrogen sulfide (281.5 g) was added over 16 minutes and stirred for 3 hours and 20 minutes below 8° C. After being stirred for 1 hour at 40° to 47° C., the mixture was poured into ice-water (10.5 l) with stirring. The resulting mixture was neutralized with 6N-aqueous hydrochloric acid and further stirred for 30 minutes. The resulting precipitates were collected by filtration, washed with water (1 l×5 times) and dried at 50° C. under reduced pressure to give 5-methoxy-2-benzofurancarbothioamide (408.2 g).

Provenance & Evidence