反应详情

To a cooled mixture of 4-tert-butyl-2-(5-formylbenzofuran-2-yl)thiazole (2.85 g) in methanol (28 ml), sodium borohydride (0.38 g) was added in small portions. After being stirred at the same temperature for 2 hours, the resulting solution was poured into ice-water. The resulting precipitates were collected by filtration and washed with water to give 4-tert-butyl-2-(5-hydroxymethylbenzofuran-2-yl)thiazole (2.87 g).

1. additionwas added in small portions
2. customThe resulting precipitates
3. filtrationwere collected by filtration
4. washwashed with water