Hydrochloric Acid → 4-Tert-butyl-2-[5-{2-(2-carboxyphenyl)ethyl}benzofuran-2-yl]thiazole

Participants

Reaction Steps

To a solution of 4-tert-butyl-2-[5-{2-(2-ethoxycarbonylphenyl)ethyl}benzofuran-2-yl]thiazole (170 mg) in methanol (5 ml), 1N aqueous sodium hydroxide (1.58 ml) was added. The resulting mixture was heated under reflux for 9 hours. After being cooled, 1N hydrochloric acid was added. The resulting precipitates were collected by filtration, and washed by water to give 4-tert-butyl-2-[5-{2-(2-carboxyphenyl)ethyl}benzofuran-2-yl]thiazole (86.3 mg).

Provenance & Evidence