HCID 19092743, compound → HCID 19092778, compound

Participants

Reaction Steps

A mixture of 4-tert-butyl-2-[5-{2-(2,2-dicarboxyethyl)phenylmethoxy}benzofuran-2-yl]thiazole (1.30 g) in xylene (20 ml) was refluxed with stirring for 7 hours. After being cooled, the mixture was subjected to column chromatography on silica gel (45 g) and eluted with a mixture of methanol and chloroform. The fractions containing object compound were combined and concentrated under reduced pressure. The residue was recrystallized from a mixture of diethyl ether and petroleum ether to give 4-tert-butyl-2-[5-{2-(2-carboxyethyl)phenylmethoxy}benzofuran-2-yl]thiazole (0.86 g).

Provenance & Evidence