Potassium Iodide → HCID 19092812, compound

Participants

Reaction Steps

A mixture of 4-chloromethyl-2-(5-hydroxybenzofuran-2-yl)thiazole (1.38 g), potassium iodide 0.58 g) and tert-butylamine (6 ml) in N,N-dimethylformamide (6 ml) was stirred overnight at ambient temperature, poured into brine and extracted with ethyl acetate. The extract was washed with water and brine. The solution was dried over magnesium sulfate and concentrated under reduced pressure. The resulting precipitate were washed with ethyl acetate to give 4-(tert-butylaminomethyl)-2-(5-hydroxybenzofuran-2-yl)thiazole (1.18 g).

Provenance & Evidence