Acetic Anhydride → HCID 19092746, compound

Participants

Reaction Steps

A mixture of 4-(tert-butylaminomethyl)-2-(5-hydroxybenzofuran-2-yl)thiazole (0.82 g) and acetic anhydride (0.75 g) in ethyl acetate (10 ml) was stirred under reflux for 4 hours. After being cooled, the resulting mixture was concentrated under reduced pressure. A solution of the resulting mixture in methanol (3 ml) and conc. ammonia water (1 ml) was stirred for 2 hours at ambient temperature, poured into brine, extracted with ethyl acetate, dried over magnesium sulfate and concentrated under reduced pressure to give 4-(N-acetyl-tert-butylaminomethyl)-2-(5-hydroxybenzofuran-2-yl)thiazole (0.93 g).

Provenance & Evidence