反应详情

Compound (VI) (3.6 mmole) and palladium chloride (1.4 g, 7.9 mmole) were used as in Example 1. The pressure was about 35 psig. The reaction was complete in about 1 hour and gave a 66% yield of product (VII). The amount of catalyst was 70% by weight or 2.2 moles per mole of (VI). The yield was not optimal and there was a risk of defluorination of (VI). Too much catalyst was necessary.