Hydrochloric Acid → HCID 19093039, compound

Participants

Reaction Steps

20 ml of methanol and then 5.1 ml of concentrated hydrochloric acid were added to 2.54 g of methyl 5-acetyl-3-amino-4,5,6,7tetrahydrothieno[3,2-c]pyridine-2-carboxylate (Compound No. 16) obtained in Example 1. The resultant mixture was heated under reflux for 4 hours. After cooling, the crystals thus formed were taken by filtration to obtain 1.70 g (68%) of methyl 3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate hydrochloride.

Provenance & Evidence