Benzyl Bromide → HCID 14888726, compound

Participants

Reaction Steps

To a stirred suspension of 1,1-dimethylethyl 4-(carboxymethyl)phenylpropanoate (5.3 g. 20.0 mmol) and potassium carbonate (2.8 g. 20.0 mmol) in DMF (30 mL) was added benzyl bromide (3.42 g. 20 mmol). After stirring for 24 h. the solvent was removed in vacuo and the residue was extracted with hexanes (100 mL). Filtration and removal of the solvent under reduced pressure gave 1,1-dimethylethyl 3-[4-(2-benzyloxy-2-oxo-ethyl)phenyl]propanoate (6.5 g. 18.4 mmol) as a colorless liquid in 92% yield.

Provenance & Evidence