Pyridine → HCID 57250718, compound

Participants

Reaction Steps

A solution of FR-900506 (500 mg) in dry dichloromethane (25 ml) was added dropwise over 1 minute to a stirred, cool (0° C.) solution of thionyl chloride (0.45 ml) and pyridine (1.11 ml) in dry dichloromethane (20 ml) under nitrogen. After 20 minutes, saturated aqueous sodium hydrogen carbonate solution was added and the mixture was stirred at room temperature for 20 minutes. The organic extract was then separated and washed with dilute aqueous hydrochloric acid (1M, 20 ml), water (20 ml) and brine (10 ml) before being dried (MgSO4), filtered and evaporated in vacuo to give the sub-title compound as an an oil (512 mg).

Provenance & Evidence