Methyl iodide → Ethyl 2-(3-methoxyphenyl)-2-methylbutyrate

Participants

Reaction Steps

The ethyl 2-(3-hydroxyphenyl)-2-methylbutyrate used as a starting material was obtained using the procedures described in the portion of Example 1 which is concerned with the preparation of starting materials except that methyl iodide was used in place of ethyl iodide in the second alkylation step. The intermediate so obtained, ethyl 2-(3-methoxyphenyl)-2-methylbutyrate, gave the following characteristic NMR signals: 0.84 (t, 3 H), 1.19 (t, 3 H), 1.5 (s, 3 H), 1.85-2.15 (m, 2 H), 3.8 (s, 3 H), 4.13 (q, 2 H), 6.72-6.92 (m, 3 H), 7.21 (m, 1 H).

Provenance & Evidence