Pyridine → HCID 131718369, compound

Participants

Reaction Steps

A solution of N-(1-methylpropyl)-β-chloroethoxycarbamyl-β-alaninyl chloride [prepared from 9.8 g (0.05 mol) of 7 and 10 mL of SOCl2 as described earlier]in 20 ML of CHCl3 was added to a solution of 4 g (0.055 mol) of sec-butylamine and 4.4 g (0.055 mol) of pyridine in 50 mL of CHCl3 at dry ice-acetone temperature. After 16 h the reaction mixture was worked up as described earlier to give 7.05 g (58%) of 51: mp 97°-98° C.; 1H NMR (CDCl3) δ 0.89 (t, 3, CH2CH3), 1.12 (d, 3, CHCH3), 1.45 (m, 2, CH2CH3) 2.40 (t, 2, CH2CO) , 3.46 (m, 2, NCH2) , 3.65 (t, 2, CH2Cl), 3.92 (m, 1, NHCH--) and 4.29 (t, 2, --CH2OCO).

Provenance & Evidence