HCID 19091455, compound → HCID 67825685, compound

HRID 487901Notes

Reaction equation

HRID 487901 reaction equation
C(OC1C=C2C(C(=O)C(Br)CO2)=CC=1)C1C=CC=CC=1.[CH2:21]([O:28][C:29]1[CH:38]=[C:37]2[C:32]([C:33](=[O:46])[CH:34]([O:39][C:40]3[CH:41]=[N:42][CH:43]=[CH:44][CH:45]=3)[CH2:35][O:36]2)=[CH:31][CH:30]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:21]([O:28][C:29]1[CH:38]=[C:37]2[C:32]([C@H:33]([OH:46])[C@H:34]([O:39][C:40]3[CH:41]=[N:42][CH:43]=[CH:44][CH:45]=3)[CH2:35][O:36]2)=[CH:31][CH:30]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 19091455HCID 19091455, compoundHCID 19091458HCID 19091458, compound

Product 1

HCID 67825685HCID 67825685, compound

Procedure

By the method of Example 1, 7-benzyloxy-3-bromo-4-chromanone was converted to 7-benzyloxy-3-(3-pyridyloxy)-4-chromanone, which, by the method of Example 2 was converted to present title product, mp 73°-75° C.; HRMS 349.1302, calcd. 349 1315; 1H-NMR (300 MHz, CDCl3) includes delta 5.04 (s, 2H).

Sources & evidence

ORD record
ord-d26c556d330646f9a67bb51ff7344e05
Source dataset
uspto-grants-1994_03
Patent number
US05298512

Reaction notes

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