Triethylamine → N-(2-Nitrooxyethyl)-5,5-dimethyl-2-oxothiazolidine-4-carboxamide

1.38 ml of triethylamine and 0.37 ml of diethyl cyanophosphonate were added, whilst ice-cooling and stirring, to a suspension of 360 mg of 5,5-dimethyl-2-oxothiazolidine-4-carboxylic acid and 417 mg of N-(2-nitrooxyethyl)amine nitrate in 50 ml of dry tetrahydrofuran, and the resulting mixture was stirred at room temperature for 4 hours, after which the solvent was removed by distillation under reduced pressure. The residue was mixed with ethyl acetate, and the resulting mixture was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure. The residual pale yellow oil was purified by column chromatography through silica gel, using a 50:1 by volume mixture of methylene chloride and methanol as the eluent. The crystals thus obtained were recrystallized from diethyl ether, to give 180 mg of the title compound as colorless crystals, melting at 98°-100° C.

1. temperaturecooling
2. customafter which the solvent was removed by distillation under reduced pressure
3. additionThe residue was mixed with ethyl acetate
4. washthe resulting mixture was washed with a saturated aqueous solution of sodium chloride
5. dry with materialdried over anhydrous magnesium sulfate
6. customThe solvent was then removed by distillation under reduced pressure
7. customThe residual pale yellow oil was purified by column chromatography through silica gel
8. additionby volume mixture of methylene chloride and methanol as the eluent
9. customThe crystals thus obtained
10. customwere recrystallized from diethyl ether

ORD record

ord-619b77d1ebb342818e9fbf124cbac8a6

Source dataset

uspto-grants-1994_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05298516