Ethyl bromoacetate → [2-(Benzylcarbamoyl-methyl)-l-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]-acetic acid ethyl ester

HRID 48800Notes

Reaction equation

HRID 48800 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:6][CH:7]1[C:16]2[C:11](=[CH:12][C:13]([O:18][CH3:19])=[C:14]([OH:17])[CH:15]=2)[CH2:10][CH2:9][N:8]1[CH2:20][C:21]([NH:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22].Br[CH2:37][C:38]([O:40][CH2:41][CH3:42])=[O:39]>>[CH2:41]([O:40][C:38](=[O:39])[CH2:37][O:17][C:14]1[CH:15]=[C:16]2[C:11]([CH2:10][CH2:9][N:8]([CH2:20][C:21](=[O:22])[NH:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:7]2[CH2:6][C:5]2[CH:31]=[CH:32][C:33]([O:34][CH3:35])=[C:3]([O:2][CH3:1])[CH:4]=2)=[CH:12][C:13]=1[O:18][CH3:19])[CH3:42]

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 227427542-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

Product 1

HCID 69895850[2-(Benzylcarbamoyl-methyl)-l-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]-acetic acid ethyl ester

Procedure

prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with ethyl bromoacetate

Sources & evidence

ORD record
ord-3dd494a12a9749a296684abe6a09a1f3
Source dataset
uspto-grants-2004_03
Patent number
US06703392B2

Reaction notes

Loading…