Acetic Anhydride → HCID 14986483, compound

HRID 488141Notes

Reaction equation

HRID 488141 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH2:12][CH2:13][CH3:14])[C:5](/[CH:15]=[C:16](\[CH3:20])/[C:17]([OH:19])=[O:18])=[CH:4][C:3]=1[O:21][CH3:22].[C:23](OC(=O)C)(=[O:25])[CH3:24]>N1C=CC=CC=1>[C:23]([O:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH2:12][CH2:13][CH3:14])[C:5](/[CH:15]=[C:16](/[CH3:20])\[C:17]([OH:19])=[O:18])=[CH:4][C:3]=1[O:21][CH3:22])(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 10086171HCID 10086171, compound

Product 1

HCID 14986483HCID 14986483, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

7.1 g of (E)-3-(4-hydroxy-3-methoxy-5-propyl-1-naphthyl)-2-methylpropenoic acid was dissolved in 20 ml of pyridine and 2 ml of acetic anhydride was added, followed by stirring at room temperature overnight. The reaction mixture was concentrated in vacuo and the resultant crystals were filtered and washed with ethyl acetate to obtain 7.5 g of the titled compound as colorless crystals.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationthe resultant crystals were filtered
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-882c167bf9f74c83bbc43755e4a70285
Source dataset
uspto-grants-1994_03
Patent number
US05298649

Reaction notes

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