反应详情

Jones reagent (a 2.6M solution in sulfuric acid; 0.13 ml, 0.36 mmol) was added dropwise to a solution of 4-(5-hydroxy-3-hexadecynyl)-2-triethylsilylfuran (136.4 mg, 0.33 mmol) in acetone (5 ml) at 0 degrees. After 20 minutes, the excess Jones reagent was destroyed with ethanol (ca 1 ml) and the mixture was diluated with water. The organic phase was separated, dried (magnesium sulfate) and evaporated down to give an oil, which was purified by preparative silica plates to give the titled ketone.

1. customthe excess Jones reagent was destroyed with ethanol (ca 1 ml)
2. customThe organic phase was separated
3. dry with materialdried (magnesium sulfate)
4. customevaporated down
5. customto give an oil, which
6. customwas purified by preparative silica plates