Sodium Hydroxide → HCID 19091792, compound

Participants

Reaction Steps

A solution of 3.0 g (5.2 mmol) of N-(2-ethoxy-2-oxoethyl)-N-[3-(1-oxooctadecylamino)benzoyl]glycine ethyl ester and 25 ml (25 mmol) of 1N NaOH in 100 ml of methanol was stirred at reflux for 6 hours. The solvent was removed at reduced pressure, the residue was acidified and the precipitate was filtered and recrystallized from ethyl acetate-hexane to give 2.0 g (74% yield, mp 132°-142° ) of N-(carboxymethyl)-N-[3-(1-oxooctadecylamino)benzoyl]glycine.

Provenance & Evidence