Sodium Hydroxide → N-(carboxymethyl)-N-[3-[3-(phenoxy)propoxy]-5-(octadecyloxy)benzoyl]glycine
Reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:53])[CH2:7][N:8]([CH2:47][C:48]([O:50]CC)=[O:49])[C:9](=[O:46])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH:13]=[C:12]([O:35][CH2:36][CH2:37][CH2:38][O:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH:11]=1)C>>[C:48]([CH2:47][N:8]([C:9](=[O:46])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH:13]=[C:12]([O:35][CH2:36][CH2:37][CH2:38][O:39][C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:11]=1)[CH2:7][C:6]([OH:53])=[O:5])([OH:50])=[O:49]Participants
3
Procedure
Sodium hydroxide hydrolysis of N-(2-ethoxy-2-oxoethyl)-N-[3-[3-(phenoxy)propoxy]-5-(octadecyloxy)benzoyl]glycine ethyl ester as in Example 11 gave N-(carboxymethyl)-N-[3-[3-(phenoxy)propoxy]-5-(octadecyloxy)benzoyl]glycine, mp 86°-90°.
Sources & evidence
- ORD record
- ord-491a301041f64b6b9ce20d7a8d567bd8
- Source dataset
- uspto-grants-1994_03
- Patent number
- US05298652
Reaction notes
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