Thionyl Chloride → N-(2-methoxy-2-oxoethyl)-N-[3-nitro-5-(octadecyloxy)benzoyl]glycine methyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Thionyl Chloride	HCID 24386	—
Edukt	Methyl 2-[(2-methoxy-2-oxoethyl)amino]acetate	HCID 428827	—
Edukt	3-Nitro-5-(octadecyloxy)benzoic acid	HCID 19388943	—
Produkt	N-(2-methoxy-2-oxoethyl)-N-[3-nitro-5-(octadecyloxy)benzoyl]glycine methyl ester	HCID 19091793	79%

Reaktionsschritte

Conversion of 3-nitro-5-(octadecyloxy)benzoic acid to the acid chloride with thionyl chloride followed by treatment with dimethyl iminodiacetate gave a 79% yield of N-(2-methoxy-2-oxoethyl)-N-[3-nitro-5-(octadecyloxy)benzoyl]glycine methyl ester as an oil after chromatography on silica gel using 25% ethyl acetate-hexane. The nmr spectrum was consistent with the structure.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05298652
Quelldatensatz	uspto-grants-1994_03
ORD ID	ord-b159704409d14b8095666a4585619db6
Quellennotiz	uspto-grants-1994_03