Sodium Hydroxide → N-(carboxymethyl)-N-[3,4-bis(tetradecyloxy)benzoyl]glycine

Participants

Reaction Steps

A solution of 0.90 g (1.3 mmol) of N-(2-methoxy-2-oxoethyl)-N-[3,4-bis(tetradecyloxy)benzoyl]glycine methyl ester and 1.0 ml (6 mmol) of 6N NaOH in 80 ml of methanol and 35 ml of dioxane was stirred at reflux for 6 hours. The solvents were removed at reduced pressure, the residue was acidified and the product was removed by filtration. Recrystallization from ethyl acetate-hexane gave 0.51 g (59% yield, mp 84°-87° ) of N-(carboxymethyl)-N-[3,4-bis(tetradecyloxy)benzoyl]glycine.

Provenance & Evidence