N-(3,5-dinitrobenzoyl)-N-(2-ethoxy-2-oxoethyl)glycine ethyl ester → N-(3,5-diaminobenzoyl)-N-(2-ethoxy-2-oxoethyl)glycine ethyl ester

関与物質

反応手順

A mixture of 5.95 g of N-(3,5-dinitrobenzoyl)-N-(2-ethoxy-2-oxoethyl)glycine ethyl ester and 0.75 g of 10% palladium on carbon in 75 ml of THF was shaken under an initial hydrogen pressure of 54 psi in a Parr Hydrogenator until uptake ceased after 2.5 hours. The catalyst was removed by filtration and the filtrate was concentrated at reduced pressure to give 4.9 g of N-(3,5-diaminobenzoyl)-N-(2-ethoxy-2-oxoethyl)glycine ethyl ester as a yellow oil. The mass spectrum was compatible with the structure.

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