反应详情

A suspension of 2.4 g (4.7 mmol) of 5-(octadecyloxy)-2-(phenylmethoxy)benzoic acid methyl ester in 70 ml of methanol and 23 ml (23 mmol) of 1.0N NaOH was stirred at reflux for 4 hours when a clear solution was obtained. The solvent was removed at reduced pressure and the residue was treated with water, acidified to pH 1 with 3N HCl and the product was extracted with chloroform. The dried extract was concentrated to a solid which was recrystallized from ether-hexane to give 2.33 g (99% yield, mp 80°-81°) of 5-(octadecyloxy)-2-(phenylmethoxy)benzoic acid.

1. temperatureat reflux for 4 hours when a clear solution
2. customwas obtained
3. customThe solvent was removed at reduced pressure
4. additionthe residue was treated with water
5. extractionthe product was extracted with chloroform
6. extractionThe dried extract
7. concentrationwas concentrated to a solid which
8. customwas recrystallized from ether-hexane