Sodium Hydroxide → HCID 19091767, compound

Participants

Reaction Steps

To 2.98 g (6.9 mmol) of 3-(octadecyloxy)-alpha-oxobenzeneacetic acid methyl ester in 200 ml of hot methanol was added 7.6 ml (7.6 mmol) of 1N NaOH. The solution was stirred at reflux for 5 minutes and the solvent was then removed under reduced pressure. The residue was treated with water and 15 ml of 1N HCl and the product was extracted with ethyl acetate. The dried extract was concentrated to a solid which was recrystallized form acetone-hexane to give 2.5 g (88% yield, mp 77°-79°) of 3-(octadecyloxy)-alpha-oxobenzeneacetic acid.

Provenance & Evidence