反应详情

温度

65 °C

4-Methylresorcinol (25.8 g, 0.208 mol) and succinic anhydride (20.8 g, 0.208 g) were placed in a round bottom flask and the flask was purged with nitrogen. Methanesulfonic acid (150 mL) was added and the solution heated under nitrogen to 65° C. for 2 hours. The solution was added dropwise to 1 L of rapidly stirred, ice-cooled water with the simultaneous addition of 50% aq sodium hydroxide to maintain the pH at 2.25 +/-0.25. The product was collected by centrifugation and washed with water (3×) and acetone (2×). The solid was air-dried, then vacuum-dried at 110° C. to afford a brick-red powder (24.1 g, 74%).

1. customthe flask was purged with nitrogen
2. additionMethanesulfonic acid (150 mL) was added
3. additionThe solution was added dropwise to 1 L
4. temperatureice-cooled water
5. additionwith the simultaneous addition of 50% aq sodium hydroxide
6. temperatureto maintain the pH at 2.25 +/-0.25
7. customThe product was collected by centrifugation
8. washwashed with water (3×) and acetone (2×)
9. customThe solid was air-dried
10. customvacuum-dried at 110° C.