Sodium Hydroxide → HCID 19091758, compound

Participants

Reaction Steps

A solution of 1.3 g (2.2 mmol) of N-(2-ethoxy-2-oxoethyl)-N-[2-[3-(octadecyloxy)phenyl]-1,2-dioxoethyl]glycine ethyl ester and 1.8 ml (11 mmol) of 6N NaOH in 100 ml of methanol was stirred at reflux under argon for 3 hours. The solvent was removed at reduced pressure, the residue was acidified and the product was extracted with ethyl acetate. The dried extract was concentrated at reduced pressure to a solid which was recrystallized from acetone-hexane to give 1.08 g (91% yield, mp 126°-128°) of N-(carboxymethyl)-N-[2-[3-(octadecyloxy)phenyl]-1,2-dioxoethyl]glycine.

Provenance & Evidence