Sodium Hydroxide → HCID 19091862, compound

Participants

Reaction Steps

A solution of 1.2 g (1.9 mmol) of N-[[3,5-bis(decyloxy)phenyl]-1,2-dioxoethyl]-N-(2-ethoxy-2-oxoethyl)glycine ethyl ester in 75 ml of methanol and 1.6 ml (9.6 mmol) of 6.0 N NaOH was stirred at reflux under argon for 4 hours. The solvent was removed at reduced pressure, the residue was treated with water and 2.5 ml of 6N HCl and the product was extracted with ethyl acetate. The dried extract was concentrated to a foam which was crystallized from hexane to give 0.96 g (87% yield, mp 76°-78°) of N-(carboxymethyl)-N-[[3,5-bis(decyloxy)phenyl]-1,2-dioxoethyl]glycine.

Provenance & Evidence