Sodium Hydroxide → HCID 19091827, compound

HRID 488319Notes

Reaction equation

[OH-].[Na+].C([O:5][C:6](=[O:52])[CH2:7][N:8]([CH2:46][C:47]([O:49]CC)=[O:48])[C:9](=[O:45])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH:13]=[CH:12][C:11]=1[O:35][CH2:36][CH2:37][CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)C>>[C:47]([CH2:46][N:8]([C:9](=[O:45])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH:13]=[CH:12][C:11]=1[O:35][CH2:36][CH2:37][CH2:38][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1)[CH2:7][C:6]([OH:52])=[O:5])([OH:49])=[O:48]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 19091886HCID 19091886, compound

Product 1

HCID 19091827HCID 19091827, compoundYield 82%

Procedure

Sodium hydroxide hydrolysis of N-(2-ethoxy-2-oxoethyl)-N-[5-(octadecyloxy)-2-(3-phenylpropoxy)benzoyl]glycine ethyl ester under conditions described in Example 81 gave N-(carboxymethyl)-N-[5-(octadecyloxy)-2-(3-phenylpropoxy)benzoyl]glycine 82% yield, mp 101°-102°).

Sources & evidence

ORD record: ord-68a41a1e8bf6404bbc34d4a3e8931acb
Source dataset: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05298652

Reaction notes

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