Sodium Hydroxide → HCID 19091850, compound

HRID 488321Notes

Reaction equation

[OH-].[Na+].C([O:5][C:6](=[O:61])[CH2:7][N:8]([CH2:55][C:56]([O:58]CC)=[O:57])[C:9](=[O:54])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH:13]=[CH:12][C:11]=1[O:35][CH2:36][CH2:37][CH2:38][O:39][C:40]1[CH:45]=[CH:44][C:43]([O:46][CH2:47][C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)=[CH:42][CH:41]=1)C>>[C:56]([CH2:55][N:8]([C:9](=[O:54])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH:13]=[CH:12][C:11]=1[O:35][CH2:36][CH2:37][CH2:38][O:39][C:40]1[CH:45]=[CH:44][C:43]([O:46][CH2:47][C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)=[CH:42][CH:41]=1)[CH2:7][C:6]([OH:61])=[O:5])([OH:58])=[O:57]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 19091808HCID 19091808, compound

Product 1

HCID 19091850HCID 19091850, compoundYield 79%

Procedure

Sodium hydroxide hydrolysis of N-(2-ethoxy-2-oxoethyl)-N-[5-(octadecyloxy)-2-[3-[4-(phenylmethoxy)phenoxy]propoxy]benzoyl] glycine ethyl ester under conditions described in Example 81 gave N-(carboxymethyl)-N-[5-(octadecyloxy)-2-[3-[4-(phenylmethoxy)phenoxy]propoxy]benzoyl]glycine (79% yield, mp 70°-74° ).

Sources & evidence

ORD record: ord-256174d59d7c4440a1d8348da41a5a7a
Source dataset: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05298652

Reaction notes

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