Lawesson's reagent → HCID 69733914, compound

Participants

Reaction Steps

Following the general procedure of Example 5, and making non-critical variations but substituting (−)-N-[[(5S)-3-(3,4-dihydro-1H-2-benzopyran-7-yl)-2-oxo-5-oxazolidinyl]methyl]acetamide (Step 4) for methyl 6-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate, using 0.7 mol-equivalents of Lawesson's reagent and repurifying the product by trituration with MeOH/Et2O or recrystallization from EtOAc/hexane, the title compound is obtained (84%) as a white solid, mp 165° C. (decomp.). MS (ESI+) for C15H18N2O3S m/z 307 (M+H)+; [α]25D=6° (c 0.96, DMSO).

Provenance & Evidence