Water → HCID 60054148, compound

Participants

Reaction Steps

A solution of NaIO4 (220 mg, 1.03 mmol) in H2O (4.1 mL) is treated with a solution of (−)-N-[[(5S)-3-(3,4-dihydro-1H-2-benzothiopyran-7-yl)-2-oxo-5-oxazolidinyl]methyl]acetamide (Example 14, 300 mg, 0.979 mmol) in MeOH (20 mL) over approximately 1 min, and the resulting mixture is stirred at ambient temperature for 18 hrs. The mixture is then diluted with brine (25 mL) and extracted with 10% MeOH/CH2Cl2 (4×25 mL), and the combined organic phase is dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue is chromatographed on a Flash 40S silica gel (40 g, 32-63 μm) cartridge, eluting with a gradient of MeOH/CH2Cl2 (2/98-8/92), and those fractions with an Rf=0.20 by TLC (MeOH/CHCl3, 10/90) are pooled and concentrated to give 293 mg (93%) of the title compound (mixture of diastereomers) as an amorphous, white solid.

Provenance & Evidence