tert-Butyl methyl ether → Methyl 7-amino-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Participants

Reaction Steps

A mixture of the compound from Step 1 (50 g, 200 mmol) and 10% palladium on carbon (2.5 g) in ethanol (800 mL) is hydrogenated with shaking at 20 psi. Methyl t-butyl ether is added and the mixture filtered through celite and concentrated to give 44 g (100%) of the title compound as a white solid, mp 100-104° C.

Provenance & Evidence