Hydrochloric Acid → HCID 53821205, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 7.70 g 4-[(R)-(1-phenyl-ethyl)amino]-7-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-6-nitro-quinazoline in 120 ml of methanol are added 2 ml of concentrated hydrochloric acid. The reaction mixture is stirred for 1.5 hours at 50° C. After cooling, the mixture is neutralized with solid sodium bicarbonate and concentrated in vacuo. The solid residue is dissolved in ethyl acetate, washed with concentrated aqueous sodium bicarbonate solution, dried over magnesium sulfate, and concentrated. The residue is triturated with 30 ml of diethyl ether, filtered off with suction, and dried. Yield: 4,34 g (88% of theory), Melting point: 187-192° C. Mass spectrum (ESI*): m/z=355 [M+H]*

Provenance & Evidence