Acetic Anhydride → HCID 67024743, compound

Participants

Reaction Steps

47 μl of acetic anhydride and catalytic amounts of 4-dimethyl-aminopyridine are added to 250 mg of 4-[(3-chloro-4-fluorophenyl)amino]-6-[(4-{N-[(ethoxycarbonyl)methyl]-N-(2-hydroxyethyl)amino}-1-oxo-2-buten-1-yl)amino]-7-cyclopropylmethoxy-quinazoline in 2 ml of methylene chloride. The reaction mixture is stirred overnight at ambient temperatures and then evaporated to dryness. The crude product is purified by chromatography on a silica gel column with methylene chloride, followed by methylene chloride/methanol (9:1) as eluant. Yield: 150 mg (56% of theory), Melting point: 90-92° C. Mass spectrum (ESI+): m/z=614, 616 [M+H]+

Provenance & Evidence