Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tributylphosphine → (E)-(2S)-2-Ethoxy-3-{4-[3-(4-furan-2-yl-phenyl)-3-phenyl-allyloxy]-phenyl}-propionic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tributylphosphine | HCID 13831 | — |
| 반응물 | Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate | HCID 9816147 | — |
| 반응물 | (E)-3-(4-furan-2-yl-phenyl)-3-phenyl-prop-2-en-1-ol | HCID 69774305 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | (E)-(2S)-2-Ethoxy-3-{4-[3-(4-furan-2-yl-phenyl)-3-phenyl-allyloxy]-phenyl}-propionic acid ethyl ester | HCID 69774285 | 53% |
반응 단계
Reaction of (E)-3-(4-furan-2-yl-phenyl)-3-phenyl-prop-2-en-1-ol (475 mg, 1.72 mmol), tributylphosphine (0.63 ml, 2.58 mmol), (2S)-2-ethoxy-3-(4-hydroxy-phenyl)-propionic acid ethyl ester (451 mg, 1.89 mmol) and azodicarboxylic dipiperidide (650 mg, 2.58 mmol) in benzene in an identical manner to example 3 gave the title compound (450 mg, 53%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06972294B1 |
| 출처 데이터셋 | uspto-grants-2005_12 |
| ORD ID | ord-70b21f79b1144ee8b263bf11ed02fd13 |
| 출처 메모 | uspto-grants-2005_12 |