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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 488456Generated: October 29, 2026

2,6-Diimino-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid → Methyl 2,6-diamino-4-pyrimidinecarboxylate

https://huagongshe.com/reaction/488456

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Diimino-1,2,3,6-tetrahydropyrimidine-4-carboxylic acidHCID 240531—
ReactantHydrochloride methanolHCID 21893726—
ProductMethyl 2,6-diamino-4-pyrimidinecarboxylateHCID 22476528100%

Reaction Steps

2,6-diamino pyrimidine-4-carboxylic acid (G. D. Davies, F. Baiocchi, R. K. Robins and C. C. Cheng, J. Org Chem 26 (1961) 2755-2759) was esterified with HCl/MeOH using the procedure of Preparation 4, step (a) in 100% yield. 1HNMR δ(DMSO) 3.90(3H,s), 6.72 (1H,s), 8.57 (broad), 8.93 (broad).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06972297B2
Source datasetuspto-grants-2005_12
ORD IDord-ffe772257b6c4f15b4a3ea6b943eee26
Source noteuspto-grants-2005_12