HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 6-(methylamino)-3-pyridazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 6-(Methylamino)pyridazine-3-carboxylic acid | HCID 22271435 | — |
| Product | Ethyl 6-(methylamino)-3-pyridazinecarboxylate | HCID 22271465 | — |
Reaction Steps
A solution of 3-methylaminopyridazine-6-carboxylic acid (0.58 g) in ethanol (50 ml) was saturated with HCl gas, refluxed 48 hours and evaporated. The residue was partitioned between EtOAc and aqueous NaHCO3, separated and the aqueous re-extracted with EtOAc. The organic was dried and evaporated to give title compound (0.61 g). MS(+ve ion chemical ionisation) m/z 182 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06972297B2 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-a04624f73001438ab890b608c3aae5d7 |
| Source note | uspto-grants-2005_12 |